An allergy is an exaggerated and inappropriate immune system response. Conventional medicine loves to suppress symptoms.
Suppressing symptoms means getting rid of them without addressing the illness or disease. Allergies are an improper immune system response.
Many vets will prescribe Apoquel without fully disclosing the risks. In all honesty, many vets are falsely reassured by the pharmaceutical company that this medication is safe. But even the FDA is warning that it is NOT safer (read their letter to Zoetix here.)
Apoquel demolishes essential parts of your dog’s internal disease-fighting systems. This is important to understand!
The following information was written by Deva Khalsa VMD (Updated On May 1, 2020) -
Prednisone was the first conventional medication vets used for allergies. Prednisone and other steroids work by suppressing the immune system.
Then, when allergic dogs stopped responding to steroids, veterinarians started using Atopica (cyclosporine).
Cyclosporine was initially developed to prevent organ transplant rejections in humans. It suppresses the immune system to prevent the body from rejecting the transplant.
Atopica has a devastating and destructive effect on the immune system. You can read more about the Atopica and my concerns here.
Unfortunately, Atopica is still used today for some dogs. This is alarming … the FDA has 17 pages of adverse events for Atopica in dogs!
Enter the latest scary allergy drug, Apoquel. It also suppresses your dog’s immune system … but in a different way.
So … is it safer?
Apoquel affects the body’s kinases. Kinases are signaling compounds that cells use to communicate with each other.
In the 1980s, an Australian chemist discovered some new ones. They’re known as JAK1, JAK2, JAK3 and TKY2.
With the growing epidemic of dog allergies, pharmaceutical companies saw an opportunity. They developed a drug that would stop these JAKs in their tracks.
And they sure succeeded.
Oclacitinib maleate, under the brand name Apoquel®, is a Janus kinase inhibitor.
That means it stops JAKs from doing their job.
JAKs are key elements in controlling both growth and development. These particular JAKs do the work of:
- Policing the body against tumor formation
- Controlling body growth and development
- Forming white and red blood cells
- Ensuring antibody-producing B cells, and “policing” T-cells are functioning well.
- Regulating inflammatory response
Apoquel’s mechanism is to interrupt JAKs … and prevent them from working.
Without JAKs your dog’s immune system cannot function correctly.
JAK1 is vital for the constant surveillance within your dog’s body. Its job is to find and destroy abnormal cells that have become cancerous … before they form tumors.
JAK1 is a crucial messenger. It’s needed to destroy invading parasites, fungi, bacteria and viruses.
JAK2 is central to the production of bone marrow stem cells. These cells then become red and white blood cells and platelets.
Your dog’s antibody system (B cells) and its killer-cell system (T cells) need JAK3 in order to work properly.
These JAKs all talk to each other and share information to keep your dog’s body healthy.
So you can see that by preventing JAKs from working … Apoquel undermines your dog’s immune system.
Read more: https://www.dogsnaturallymagazine.com/wouldnt-give-dog-new-allergy-drug/
So can Apoquel cause cancer?
The following information was written November 24, 2019 By Will Falconer, DVM:
Did you know that, for decades now at least, immunologists have known that you and I and every animal on the beautiful blue planet are making “mistakes” in our cells every day?
They are called mutations.
Mutations happen during cell division, which is pretty much a non-stop process in a living being. When you’ve worn out a liver cell or you’ve got to knit a cut back to normal closed skin, it’s cell division that makes this possible.
But, like all biological systems, cell division isn’t a perfect process.
Some “oopsies” happen, and the copy comes out wrong.
Some mutations are harmless, some, when certain genes are involved, cause runaway cell division way past what’s necessary.
The result? Tumors.
Tumor cells are in me and you and your dog right now
We likely have regular battles waged on cancer cells that never become tumors.
Our immune system correctly “saw” these cells as foreigners.
And called in the guard, like white blood cells, complement, interferon, natural killer cells, etc.
And like those kinases, known to be great communicators that help coordinate the attack on the wayward cells leaning towards becoming cancerous.
What’s Apoquel good at?
Taking OUT some of those kinases, remember?
Is an immune communication breakdown possible, when we mess with the kinases?
I’d bet on it.
And, it’s as if Zoetis never got the memo about how important our immune system is to prevent cancer:
APOQUEL may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or **pre-existing cancers** (emphasis mine) to get worse. — company literature
Isn’t that what we’ve known about for all these decades?
They are ALL pre-existing until they get a green light to grow, aren’t they?
Read more here: https:/vitalanimal.com/apoquel-dog-1/
So what can we do for allergies that IS safe?
Food sensitivities and intolerances are about 15 times more common than true allergies.